Test results

Informed decisions start here

Results within two weeks so you can focus on living, not guessing.1
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Negative or Positive

Results you can act on

You’ll get a clear negative or positive result. So you’ll know if a cancer signal is present — and can make an informed plan to move forward.
No cancer signal detected

Negative results

A negative result means the test did not find signals of cancer in your blood* — 97% of tests will come back negative.1

Negative result action plan:

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Continue routine cancer screenings recommended by your doctor2
Consider retesting with Cancerguard™ as part of your annual routine care.
Cancer signal detected

Positive results

A positive result means that the test found a signal of cancer.* This does not mean you have cancer, but does mean that additional testing is needed.2

Positive result action plan:

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Your health care provider may take additional steps, like ordering imaging scans or other medical tests, that may be needed to locate and confirm a possible cancer or to rule out that cancer is present.3
Exact Sciences can work with you to schedule follow up tests.

* False negative and false positive results can occur. A false negative result means the test did not find signals of cancer, but a person does have cancer. A false positive result means the test found signals of cancer, but a person doesn’t have cancer.

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Positive Result Services

Early insights.
Real support.

A positive result may feel overwhelming, but we’re here with you. Cancerguard helps reveal what’s beneath the surface — giving you time, choices, and peace of mind.
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A grandfather laughing and hugging his granddaughter.
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World-class patient navigation

Get personalized support from a Care Navigator3 (a nurse or other health professional). It’s included and covers things like:

  • Finding location options that offer the testing your doctor orders
  • Scheduling necessary follow-up appointments
  • Providing eligibility details for patient imaging reimbursement program
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Imaging reimbursement

  • If there’s a positive result, your doctor may order an imaging test so they can determine if you have cancer.
  • You may be eligible for up to $6,000 reimbursement for non-covered imaging costs to help reduce the financial impact.†3

† Patients must apply. Eligibility depends on program qualifications and is not guaranteed. The program will not reimburse any covered imaging costs, including copay, coinsurance and/or deductible amounts determined by insurance. For more information patients should contact to apply, call 1-844-870-8870.

Peace of mind is closer than you think

HSA/FSA eligible‡
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Important Information about the Cancerguard Test

Rx only. Talk to your healthcare provider to determine if this test is right for you.

The Cancerguard™ test is indicated for use in adults ages 50-84 with no known cancer diagnosis in the last three years. It detects alterations in circulating tumor DNA and tumor-associated protein levels which are commonly associated with cancer. The test does not detect all cancers and is not a replacement for existing recommended cancer screening or diagnostic modalities for cancer. Current recommended screening for cancer should also be followed. The test is not indicated for screening of breast and prostate cancer and was not evaluated for the detection of pre-cancerous lesions. Due to the potential for follow-up imaging with IV contrast CT after a positive test result, careful consideration should be given before ordering the Cancerguard test for patients with a history of adverse reactions to iodine based IV contrast or for women who are, may be, or plan to become pregnant. Results should be interpreted in the context of a patient’s medical history, clinical signs, and symptoms. A negative result does not rule out the presence of cancer of any type. A positive Cancerguard™ test result means that the blood test identified a cancer signal that may indicate the presence of cancer. This result alone does not confirm the presence of cancer. Further clinical evaluation by a healthcare provider (which may include blood tests such as complete blood count and comprehensive metabolic panel) and follow-up imaging are needed to locate and confirm a diagnosis of cancer or determine that cancer is not present. While there are no established guidelines for imaging following a positive Cancerguard test result, there is a published follow-up workflow based on expert clinician opinion and results from an exploratory, prospective, interventional study [Kisiel et al Life (Basel) 2024 Jul 24; Lennon et al, Science, 2020]. The proposed workflow in the Kisiel et al publication includes an intravenous-contrast enhanced computed tomography (IV contrast CT of chest, abdomen/pelvis, and soft-tissue neck) and if necessary, positron emission tomography-computed tomography (18F FDG PET-CT) from the skull-base to mid-thigh. Alternative follow-up procedures (e.g. targeted imaging, endoscopic procedures, CT without IV- contrast) may be appropriate in the context of the patient’s medical history and clinical evaluation [Lennon et al, Science, 2020]. False positive and false negative test results can occur.

The Cancerguard test was developed, and the performance characteristics validated by Exact Sciences Laboratories following College of American Pathologists (CAP) and Clinical Laboratory Improvement Amendments (CLIA) regulations. This test has not been cleared or approved by the US Food and Drug Administration. The test is performed at Exact Sciences Laboratories. Exact Sciences Laboratories is accredited by CAP, certified under CLIA regulations, and qualified to perform high-complexity clinical laboratory testing.